Publications & Patents

  1. Spanos, M, Gokulnath, P, Li, G, Hutchins, E, Meechoovet, B, Sheng, Q et al.. Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and disease. medRxiv. 2024; :. doi: 10.1101/2024.09.19.24314009. PubMed PMID:39371135 PubMed Central PMC11451713.
  2. Davenport, A, Kessinger, CW, Pfeiffer, RD, Shah, N, Xu, R, Abel, ED et al.. Comparative analysis of two independent Myh6-Cre transgenic mouse lines. J Mol Cell Cardiol Plus. 2024;9 :. doi: 10.1016/j.jmccpl.2024.100081. PubMed PMID:39323506 PubMed Central PMC11423776.
  3. Sun, Y, Dinenno, FA, Tang, P, Kontaridis, MI. Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics. Front Cardiovasc Med. 2024;11 :1445739. doi: 10.3389/fcvm.2024.1445739. PubMed PMID:39238503 PubMed Central PMC11374623.
  4. Perry, AS, Amancherla, K, Huang, X, Lance, ML, Farber-Eger, E, Gajjar, P et al.. Clinical-transcriptional prioritization of the circulating proteome in human heart failure. Cell Rep Med. 2024;5 (9):101704. doi: 10.1016/j.xcrm.2024.101704. PubMed PMID:39226894 PubMed Central PMC11524958.
  5. Farley, A, Gao, Y, Sun, Y, Zohrabian, S, Pu, WT, Lin, Z et al.. Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. Cells. 2024;13 (16):. doi: 10.3390/cells13161342. PubMed PMID:39195232 PubMed Central PMC11352427.
  6. Zhou, P, Kessinger, CW, Gu, F, Davenport, A, King, JS, Wang, G et al.. Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue. bioRxiv. 2024; :. doi: 10.1101/2024.07.09.602788. PubMed PMID:39026854 PubMed Central PMC11257599.
  7. Chouhan, S, Sridaran, D, Weimholt, C, Luo, J, Li, T, Hodgson, MC et al.. SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis. Nat Commun. 2024;15 (1):5629. doi: 10.1038/s41467-024-49978-4. PubMed PMID:38965223 PubMed Central PMC11224269.
  8. Li, X, Yang, J, Zhou, X, Dai, C, Kong, M, Xie, L et al.. Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption. Nat Metab. 2024;6 (7):1397-1414. doi: 10.1038/s42255-024-01072-1. PubMed PMID:38937659 .
  9. Le Sommer, S, Sun, Y, Legler, L, Nelson, K, Coon, L, Bohler, D et al.. Detection and Eradication of a Demodex Infestation in Specific Pathogen-free High-barrier Laboratory Mouse Facility Housing Immunocompromised Animals. J Am Assoc Lab Anim Sci. 2024;63 (5):521-9. doi: 10.30802/AALAS-JAALAS-23-000092. PubMed PMID:38908907 PubMed Central PMC11467872.
  10. Ikegami, R, Piao, Z, Iglesias, JF, Pilgrim, T, Ha, K, McCarthy, JR et al.. Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects. EuroIntervention. 2024;20 (10):e669-e680. doi: 10.4244/EIJ-D-23-00563. PubMed PMID:38776143 PubMed Central PMC11100507.
  11. Winston, T, Song, Y, Shi, H, Yang, J, Alsudais, M, Kontaridis, MI et al.. Lineage-Specific Mesenchymal Stromal Cells Derived from Human iPSCs Showed Distinct Patterns in Transcriptomic Profile and Extracellular Vesicle Production. Adv Sci (Weinh). 2024;11 (28):e2308975. doi: 10.1002/advs.202308975. PubMed PMID:38757640 PubMed Central PMC11267277.
  12. Sommer, SL, Kontaridis, MI. Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women. Can J Physiol Pharmacol. 2024;102 (9):511-522. doi: 10.1139/cjpp-2023-0420. PubMed PMID:38489782 .
  13. Owusu-Mensah, A, Treat, J, Bernardi, J, Pfeiffer, R, Goodrow, R, Tsevi, B et al.. Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome. PLoS One. 2024;19 (1):e0287206. doi: 10.1371/journal.pone.0287206. PubMed PMID:38181028 PubMed Central PMC10769013.
  14. Pierpont, EI, Bennett, AM, Schoyer, L, Stronach, B, Anschutz, A, Borrie, SC et al.. The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy. Am J Med Genet A. 2024;194 (4):e63477. doi: 10.1002/ajmg.a.63477. PubMed PMID:37969032 PubMed Central PMC10939912.
  15. Bose, RJ, Kessinger, CW, Dhammu, T, Singh, T, Shealy, MW, Ha, K et al.. Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Postmyocardial Infarction. Adv Mater. 2024;36 (8):e2304615. doi: 10.1002/adma.202304615. PubMed PMID:37934471 PubMed Central PMC10922695.
  16. Le Sommer, S. The rising tide raises all ships. Immunol Cell Biol. 2024;102 (2):93-96. doi: 10.1111/imcb.12681. PubMed PMID:37580062 .
Search PubMed

  1. Arduini, A, Fleming, SJ, Xiao, L, Hall, AW, Akkad, AD, Chaffin, M et al.. Transcriptional profile of the rat cardiovascular system at single cell resolution. bioRxiv. 2023; :. doi: 10.1101/2023.11.14.567085. PubMed PMID:38014050 PubMed Central PMC10680727.
  2. Pierpont, EI, Bennett, AM, Schoyer, L, Stronach, B, Anschutz, A, Borrie, SC et al.. The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy. Am J Med Genet A. 2024;194 (4):e63477. doi: 10.1002/ajmg.a.63477. PubMed PMID:37969032 PubMed Central PMC10939912.
  3. Bose, RJ, Kessinger, CW, Dhammu, T, Singh, T, Shealy, MW, Ha, K et al.. Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Postmyocardial Infarction. Adv Mater. 2024;36 (8):e2304615. doi: 10.1002/adma.202304615. PubMed PMID:37934471 PubMed Central PMC10922695.
  4. Le Sommer, S. The rising tide raises all ships. Immunol Cell Biol. 2024;102 (2):93-96. doi: 10.1111/imcb.12681. PubMed PMID:37580062 .
  5. Jameson, HS, Hanley, A, Hill, MC, Xiao, L, Ye, J, Bapat, A et al.. Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias. Circ Res. 2023;133 (4):313-329. doi: 10.1161/CIRCRESAHA.123.323029. PubMed PMID:37449401 PubMed Central PMC10527554.
  6. Lin, Z. More than a key-the pathological roles of SARS-CoV-2 spike protein in COVID-19 related cardiac injury. Sports Med Health Sci. 2023;6 (3):209-20. doi: 10.1016/j.smhs.2023.03.004. PubMed PMID:37361919 PubMed Central PMC10062797.
  7. Liu, Y, Zhong, W, Li, X, Shen, F, Ma, X, Yang, Q et al.. Diets, Gut Microbiota and Metabolites. Phenomics. 2023;3 (3):268-284. doi: 10.1007/s43657-023-00095-0. PubMed PMID:37325710 PubMed Central PMC10260722.
  8. Leu, JSL, Teoh, JJX, Ling, ALQ, Chong, J, Loo, YS, Mat Azmi, ID et al.. Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems. Pharmaceutics. 2023;15 (5):. doi: 10.3390/pharmaceutics15051421. PubMed PMID:37242663 PubMed Central PMC10224018.
  9. Tsai, EJ, Cˇiháková, D, Tucker, NR. Cell-Specific Mechanisms in the Heart of COVID-19 Patients. Circ Res. 2023;132 (10):1290-1301. doi: 10.1161/CIRCRESAHA.123.321876. PubMed PMID:37167361 PubMed Central PMC10171292.
  10. Sewanan, LR, Clerkin, KJ, Tucker, NR, Tsai, EJ. How Does COVID-19 Affect the Heart?. Curr Cardiol Rep. 2023;25 (3):171-184. doi: 10.1007/s11886-023-01841-6. PubMed PMID:36897483 PubMed Central PMC9999058.
  11. Knipe, RS, Nurunnabi, M, Probst, CK, Spinney, JJ, Abe, E, Bose, RJC et al.. Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2023;324 (2):L190-L198. doi: 10.1152/ajplung.00086.2022. PubMed PMID:36625494 PubMed Central PMC9925159.
  12. Sheldon, C, Kessinger, CW, Sun, Y, Kontaridis, MI, Ma, Q, Hammoud, SS et al.. Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells. J Mol Cell Cardiol. 2023;175 :62-66. doi: 10.1016/j.yjmcc.2022.12.005. PubMed PMID:36584478 PubMed Central PMC9974737.
  13. Amancherla, K, Qin, J, Hulke, ML, Pfeiffer, RD, Agrawal, V, Sheng, Q et al.. Single-Nuclear RNA Sequencing of Endomyocardial Biopsies Identifies Persistence of Donor-Recipient Chimerism With Distinct Signatures in Severe Cardiac Allograft Vasculopathy. Circ Heart Fail. 2023;16 (1):e010119. doi: 10.1161/CIRCHEARTFAILURE.122.010119. PubMed PMID:36524467 PubMed Central PMC9852032.
  14. Cali, E, Suri, M, Scala, M, Ferla, MP, Alavi, S, Faqeih, EA et al.. Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities. Genet Med. 2023;25 (1):135-142. doi: 10.1016/j.gim.2022.09.016. PubMed PMID:36399134 PubMed Central PMC10620944.
Search PubMed

  1. Sheldon, C, Kessinger, CW, Sun, Y, Kontaridis, MI, Ma, Q, Hammoud, SS et al.. Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells. J Mol Cell Cardiol. 2023;175 :62-66. doi: 10.1016/j.yjmcc.2022.12.005. PubMed PMID:36584478 PubMed Central PMC9974737.
  2. Amancherla, K, Qin, J, Hulke, ML, Pfeiffer, RD, Agrawal, V, Sheng, Q et al.. Single-Nuclear RNA Sequencing of Endomyocardial Biopsies Identifies Persistence of Donor-Recipient Chimerism With Distinct Signatures in Severe Cardiac Allograft Vasculopathy. Circ Heart Fail. 2023;16 (1):e010119. doi: 10.1161/CIRCHEARTFAILURE.122.010119. PubMed PMID:36524467 PubMed Central PMC9852032.
  3. Cali, E, Suri, M, Scala, M, Ferla, MP, Alavi, S, Faqeih, EA et al.. Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities. Genet Med. 2023;25 (1):135-142. doi: 10.1016/j.gim.2022.09.016. PubMed PMID:36399134 PubMed Central PMC10620944.
  4. Nandi, S, Chennappan, S, Andrasch, Y, Fidan, M, Engler, M, Ahmad, M et al.. Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model. Front Cell Dev Biol. 2022;10 :1000575. doi: 10.3389/fcell.2022.1000575. PubMed PMID:36330334 PubMed Central PMC9624175.
  5. Sheldon, C, Farley, A, Ma, Q, Pu, WT, Lin, Z. Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development. Cells. 2022;11 (18):. doi: 10.3390/cells11182832. PubMed PMID:36139407 PubMed Central PMC9496954.
  6. Eaton, DM, Berretta, RM, Lynch, JE, Travers, JG, Pfeiffer, RD, Hulke, ML et al.. Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF. Am J Physiol Heart Circ Physiol. 2022;323 (4):H797-H817. doi: 10.1152/ajpheart.00374.2022. PubMed PMID:36053749 PubMed Central PMC9550571.
  7. Glinos, DA, Garborcauskas, G, Hoffman, P, Ehsan, N, Jiang, L, Gokden, A et al.. Transcriptome variation in human tissues revealed by long-read sequencing. Nature. 2022;608 (7922):353-359. doi: 10.1038/s41586-022-05035-y. PubMed PMID:35922509 PubMed Central PMC10337767.
  8. Aromolaran, KA, Do, J, Bernardi, J, Aromolaran, AS. mTOR Modulation of IKr through hERG1b-Dependent Mechanisms in Lipotoxic Heart. Int J Mol Sci. 2022;23 (15):. doi: 10.3390/ijms23158061. PubMed PMID:35897638 PubMed Central PMC9329916.
  9. Chaffin, M, Papangeli, I, Simonson, B, Akkad, AD, Hill, MC, Arduini, A et al.. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022;608 (7921):174-180. doi: 10.1038/s41586-022-04817-8. PubMed PMID:35732739 .
  10. Calloe, K, Geryk, M, Freude, K, Treat, JA, Vold, VA, Frederiksen, HRS et al.. The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes. Europace. 2022;24 (12):2015-2027. doi: 10.1093/europace/euac090. PubMed PMID:35726875 .
  11. Yi, C, Li, D, Guo, X, Wang, J, Liu, C, Lu, G et al.. The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage. Nutrients. 2022;14 (11):. doi: 10.3390/nu14112222. PubMed PMID:35684023 PubMed Central PMC9182774.
  12. Dong, W, Kaymakcalan, H, Jin, SC, Diab, NS, Tanıdır, C, Yalcin, ASY et al.. Mutation spectrum of congenital heart disease in a consanguineous Turkish population. Mol Genet Genomic Med. 2022;10 (6):e1944. doi: 10.1002/mgg3.1944. PubMed PMID:35481623 PubMed Central PMC9184665.
  13. Kontaridis, MI, Chennappan, S. Mitochondria and the future of RASopathies: the emergence of bioenergetics. J Clin Invest. 2022;132 (8):1-5. doi: 10.1172/JCI157560. PubMed PMID:35426371 PubMed Central PMC9017150.
  14. Li, G, Manning, AC, Bagi, A, Yang, X, Gokulnath, P, Spanos, M et al.. Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs. Adv Sci (Weinh). 2022;9 (17):e2200829. doi: 10.1002/advs.202200829. PubMed PMID:35373532 PubMed Central PMC9189662.
  15. Mayakrishnan, V, Kannappan, P, Tharmalingam, N, Bose, RJC, Madheswaran, T, Ramasamy, M et al.. Bacterial cancer therapy: A turning point for new paradigms. Drug Discov Today. 2022;27 (8):2043-2050. doi: 10.1016/j.drudis.2022.03.007. PubMed PMID:35304339 .
  16. Kontaridis, MI, Roberts, AE, Schill, L, Schoyer, L, Stronach, B, Andelfinger, G et al.. The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery. Am J Med Genet A. 2022;188 (6):1915-1927. doi: 10.1002/ajmg.a.62716. PubMed PMID:35266292 PubMed Central PMC9117434.
  17. Abplanalp, WT, Tucker, N, Dimmeler, S. Single-cell technologies to decipher cardiovascular diseases. Eur Heart J. 2022;43 (43):4536-4547. doi: 10.1093/eurheartj/ehac095. PubMed PMID:35265972 PubMed Central PMC9659476.
  18. Kaymakçalan, H, Ercan-Şençiçek, AG, Cebeci, AN, Dong, W, Yalım Yalçın, AS. A rare etiology of tetralogy of Fallot with pulmonary atresia: Renpenning syndrome. Anatol J Cardiol. 2022;26 (2):149-150. doi: 10.5152/AnatolJCardiol.2021.554. PubMed PMID:35190366 PubMed Central PMC8878915.
  19. O' Brien, S, Holmes, AP, Johnson, DM, Kabir, SN, O' Shea, C, O' Reilly, M et al.. Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels. J Mol Cell Cardiol. 2022;166 :23-35. doi: 10.1016/j.yjmcc.2022.01.009. PubMed PMID:35114252 .
  20. Brener, MI, Hulke, ML, Fukuma, N, Golob, S, Zilinyi, RS, Zhou, Z et al.. Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19. JCI Insight. 2022;7 (2):. doi: 10.1172/jci.insight.154633. PubMed PMID:34905515 PubMed Central PMC8855793.
  21. Bose, RJ, Kumar, US, Garcia-Marques, F, Zeng, Y, Habte, F, McCarthy, JR et al.. Engineered Cell-Derived Vesicles Displaying Targeting Peptide and Functionalized with Nanocarriers for Therapeutic microRNA Delivery to Triple-Negative Breast Cancer in Mice. Adv Healthc Mater. 2022;11 (5):e2101387. doi: 10.1002/adhm.202101387. PubMed PMID:34879180 PubMed Central PMC8891081.
  22. Pirruccello, JP, Chaffin, MD, Chou, EL, Fleming, SJ, Lin, H, Nekoui, M et al.. Deep learning enables genetic analysis of the human thoracic aorta. Nat Genet. 2022;54 (1):40-51. doi: 10.1038/s41588-021-00962-4. PubMed PMID:34837083 PubMed Central PMC8758523.
  23. Saito, M, Moore-Lotridge, SN, Uppuganti, S, Egawa, S, Yoshii, T, Robinette, JP et al.. Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair. Osteoporos Int. 2022;33 (4):807-820. doi: 10.1007/s00198-021-06208-7. PubMed PMID:34719727 PubMed Central PMC9530779.
Search PubMed

  1. Bose, RJ, Kumar, US, Garcia-Marques, F, Zeng, Y, Habte, F, McCarthy, JR et al.. Engineered Cell-Derived Vesicles Displaying Targeting Peptide and Functionalized with Nanocarriers for Therapeutic microRNA Delivery to Triple-Negative Breast Cancer in Mice. Adv Healthc Mater. 2022;11 (5):e2101387. doi: 10.1002/adhm.202101387. PubMed PMID:34879180 PubMed Central PMC8891081.
  2. Pirruccello, JP, Chaffin, MD, Chou, EL, Fleming, SJ, Lin, H, Nekoui, M et al.. Deep learning enables genetic analysis of the human thoracic aorta. Nat Genet. 2022;54 (1):40-51. doi: 10.1038/s41588-021-00962-4. PubMed PMID:34837083 PubMed Central PMC8758523.
  3. Saito, M, Moore-Lotridge, SN, Uppuganti, S, Egawa, S, Yoshii, T, Robinette, JP et al.. Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair. Osteoporos Int. 2022;33 (4):807-820. doi: 10.1007/s00198-021-06208-7. PubMed PMID:34719727 PubMed Central PMC9530779.
  4. Chowdhury, MKH, Martinez-Mateu, L, Do, J, Aromolaran, KA, Saiz, J, Aromolaran, AS et al.. Macrophage-Dependent Interleukin-6-Production and Inhibition of IK Contributes to Acquired QT Prolongation in Lipotoxic Guinea Pig Heart. Int J Mol Sci. 2021;22 (20):. doi: 10.3390/ijms222011249. PubMed PMID:34681909 PubMed Central PMC8537919.
  5. Valkov, N, Das, A, Tucker, NR, Li, G, Salvador, AM, Chaffin, MD et al.. SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart. Life Sci Alliance. 2021;4 (12):. doi: 10.26508/lsa.202101048. PubMed PMID:34663679 PubMed Central PMC8548207.
  6. Treat, JA, Pfeiffer, R, Barajas-Martinez, H, Goodrow, RJ, Bot, C, Haedo, RJ et al.. Overlap Arrhythmia Syndromes Resulting from Multiple Genetic Variations Studied in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Int J Mol Sci. 2021;22 (13):. doi: 10.3390/ijms22137108. PubMed PMID:34281161 PubMed Central PMC8268422.
  7. Al-Yacoub, N, Colak, D, Mahmoud, SA, Hammonds, M, Muhammed, K, Al-Harazi, O et al.. Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis. Commun Biol. 2021;4 (1):884. doi: 10.1038/s42003-021-02391-9. PubMed PMID:34272480 PubMed Central PMC8285540.
  8. Kaymakcalan, H, Kaya, İ, Cevher Binici, N, Nikerel, E, Özbaran, B, Görkem Aksoy, M et al.. Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly. Mol Genet Genomic Med. 2021;9 (8):e1739. doi: 10.1002/mgg3.1739. PubMed PMID:34268892 PubMed Central PMC8404225.
  9. Akwaboah, AD, Tsevi, B, Yamlome, P, Treat, JA, Brucal-Hallare, M, Cordeiro, JM et al.. An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm. Front Physiol. 2021;12 :675867. doi: 10.3389/fphys.2021.675867. PubMed PMID:34220540 PubMed Central PMC8242263.
  10. Gao, Y, Sun, Y, Ercan-Sencicek, AG, King, JS, Akerberg, BN, Ma, Q et al.. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021;22 (13):. doi: 10.3390/ijms22136649. PubMed PMID:34206257 PubMed Central PMC8268263.
  11. Ha, K, Zheng, X, Kessinger, CW, Mauskapf, A, Li, W, Kawamura, Y et al.. In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe. ACS Sens. 2021;6 (6):2225-2232. doi: 10.1021/acssensors.1c00124. PubMed PMID:34056903 PubMed Central PMC8767556.
  12. Fidan, M, Chennappan, S, Cirstea, IC. Studying Metabolic Abnormalities in the Costello Syndrome HRAS G12V Mouse Model: Isolation of Mouse Embryonic Fibroblasts and Their In Vitro Adipocyte Differentiation. Methods Mol Biol. 2021;2262 :397-409. doi: 10.1007/978-1-0716-1190-6_24. PubMed PMID:33977491 .
  13. Hoang, P, Kowalczewski, A, Sun, S, Winston, TS, Archilla, AM, Lemus, SM et al.. Engineering spatial-organized cardiac organoids for developmental toxicity testing. Stem Cell Reports. 2021;16 (5):1228-1244. doi: 10.1016/j.stemcr.2021.03.013. PubMed PMID:33891865 PubMed Central PMC8185451.
  14. Chung, MK, Zidar, DA, Bristow, MR, Cameron, SJ, Chan, T, Harding, CV 3rd et al.. COVID-19 and Cardiovascular Disease: From Bench to Bedside. Circ Res. 2021;128 (8):1214-1236. doi: 10.1161/CIRCRESAHA.121.317997. PubMed PMID:33856918 PubMed Central PMC8048382.
  15. Kessinger, CW, Qi, G, Hassan, MZO, Henke, PK, Tawakol, A, Jaffer, FA et al.. Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging Predicts Vein Wall Scarring and Statin Benefit in Murine Venous Thrombosis. Circ Cardiovasc Imaging. 2021;14 (3):e011898. doi: 10.1161/CIRCIMAGING.120.011898. PubMed PMID:33724049 PubMed Central PMC8202732.
  16. Muus, C, Luecken, MD, Eraslan, G, Sikkema, L, Waghray, A, Heimberg, G et al.. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med. 2021;27 (3):546-559. doi: 10.1038/s41591-020-01227-z. PubMed PMID:33654293 PubMed Central PMC9469728.
  17. Yamakawa, S, Wu, D, Dasgupta, M, Pedamallu, H, Gupta, B, Modi, R et al.. Role of t-tubule remodeling on mechanisms of abnormal calcium release during heart failure development in canine ventricle. Am J Physiol Heart Circ Physiol. 2021;320 (4):H1658-H1669. doi: 10.1152/ajpheart.00946.2020. PubMed PMID:33635163 PubMed Central PMC8260383.
  18. Bose, RJ, Ha, K, McCarthy, JR. Bio-inspired nanomaterials as novel options for the treatment of cardiovascular disease. Drug Discov Today. 2021;26 (5):1200-1211. doi: 10.1016/j.drudis.2021.01.035. PubMed PMID:33561512 PubMed Central PMC8205945.
  19. Bernardi, J, Aromolaran, KA, Zhu, H, Aromolaran, AS. Circadian Mechanisms: Cardiac Ion Channel Remodeling and Arrhythmias. Front Physiol. 2020;11 :611860. doi: 10.3389/fphys.2020.611860. PubMed PMID:33519516 PubMed Central PMC7841411.
  20. Li, W, Kessinger, CW, Orii, M, Lee, H, Wang, L, Weinberg, I et al.. Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects. Circulation. 2021;143 (12):1224-1238. doi: 10.1161/CIRCULATIONAHA.120.049096. PubMed PMID:33445952 PubMed Central PMC7988304.
  21. Loo, YS, Bose, RJ, McCarthy, JR, Mat Azmi, ID, Madheswaran, T. Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications. Drug Discov Today. 2021;26 (4):902-915. doi: 10.1016/j.drudis.2020.12.017. PubMed PMID:33383213 .
  22. Chandrasekaran, R, Madheswaran, T, Tharmalingam, N, Bose, RJ, Park, H, Ha, DH et al.. Labeling and tracking cells with gold nanoparticles. Drug Discov Today. 2021;26 (1):94-105. doi: 10.1016/j.drudis.2020.10.020. PubMed PMID:33130336 .
Search PubMed

  1. Deo, M, Akwaboah, A, Tsevi, B, Treat, JA, Cordeiro, JM. Role of the rapid delayed rectifier K+ current in human induced pluripotent stem cells derived cardiomyocytes. Arch Stem Cell Ther. 2020;1 (1):14-18. doi: 10.46439/stemcell.1.003. PubMed PMID:33604593 PubMed Central PMC7889062.
  2. Bernardi, J, Aromolaran, KA, Zhu, H, Aromolaran, AS. Circadian Mechanisms: Cardiac Ion Channel Remodeling and Arrhythmias. Front Physiol. 2020;11 :611860. doi: 10.3389/fphys.2020.611860. PubMed PMID:33519516 PubMed Central PMC7841411.
  3. Loo, YS, Bose, RJ, McCarthy, JR, Mat Azmi, ID, Madheswaran, T. Biomimetic bacterial and viral-based nanovesicles for drug delivery, theranostics, and vaccine applications. Drug Discov Today. 2021;26 (4):902-915. doi: 10.1016/j.drudis.2020.12.017. PubMed PMID:33383213 .
  4. Bernardi, J, Aromolaran, KA, Aromolaran, AS. Neurological Disorders and Risk of Arrhythmia. Int J Mol Sci. 2020;22 (1):. doi: 10.3390/ijms22010188. PubMed PMID:33375447 PubMed Central PMC7795827.
  5. Pathmanathan, P, Galappaththige, SK, Cordeiro, JM, Kaboudian, A, Fenton, FH, Gray, RA et al.. Data-Driven Uncertainty Quantification for Cardiac Electrophysiological Models: Impact of Physiological Variability on Action Potential and Spiral Wave Dynamics. Front Physiol. 2020;11 :585400. doi: 10.3389/fphys.2020.585400. PubMed PMID:33329034 PubMed Central PMC7711195.
  6. Negron, SG, Ercan-Sencicek, AG, Freed, J, Walters, M, Lin, Z. Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice. Sci Rep. 2020;10 (1):20335. doi: 10.1038/s41598-020-77362-x. PubMed PMID:33230135 PubMed Central PMC7683731.
  7. Bose, RJC, Tharmalingam, N, Choi, Y, Madheswaran, T, Paulmurugan, R, McCarthy, JR et al.. Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery. Int J Nanomedicine. 2020;15 :8437-8449. doi: 10.2147/IJN.S271850. PubMed PMID:33162754 PubMed Central PMC7642590.
  8. Hall, AW, Chaffin, M, Roselli, C, Lin, H, Lubitz, SA, Bianchi, V et al.. Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation. Circ Genom Precis Med. 2020;13 (6):e003085. doi: 10.1161/CIRCGEN.120.003085. PubMed PMID:33155827 PubMed Central PMC8240092.
  9. Chandrasekaran, R, Madheswaran, T, Tharmalingam, N, Bose, RJ, Park, H, Ha, DH et al.. Labeling and tracking cells with gold nanoparticles. Drug Discov Today. 2021;26 (1):94-105. doi: 10.1016/j.drudis.2020.10.020. PubMed PMID:33130336 .
  10. Wei, Z, Lei, J, Shen, F, Dai, Y, Sun, Y, Liu, Y et al.. Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells. Adv Sci (Weinh). 2020;7 (19):2000963. doi: 10.1002/advs.202000963. PubMed PMID:33042738 PubMed Central PMC7539207.
  11. Unudurthi, SD, Luthra, P, Bose, RJC, McCarthy, JR, Kontaridis, MI. Cardiac inflammation in COVID-19: Lessons from heart failure. Life Sci. 2020;260 :118482. doi: 10.1016/j.lfs.2020.118482. PubMed PMID:32971105 PubMed Central PMC7505073.
  12. Barajas-Martinez, H, Smith, M, Hu, D, Goodrow, RJ, Puleo, C, Hasdemir, C et al.. Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes. Stem Cells Int. 2020;2020 :8842398. doi: 10.1155/2020/8842398. PubMed PMID:32952569 PubMed Central PMC7481990.
  13. Guo, H, Lu, YW, Lin, Z, Huang, ZP, Liu, J, Wang, Y et al.. Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart. Nat Commun. 2020;11 (1):4666. doi: 10.1038/s41467-020-18379-8. PubMed PMID:32938943 PubMed Central PMC7494909.
  14. van Ouwerkerk, AF, Hall, AW, Kadow, ZA, Lazarevic, S, Reyat, JS, Tucker, NR et al.. Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation. Circ Res. 2020;127 (1):34-50. doi: 10.1161/CIRCRESAHA.120.316574. PubMed PMID:32717170 PubMed Central PMC8315291.
  15. Yoo, S, Pfenniger, A, Hoffman, J, Zhang, W, Ng, J, Burrell, A et al.. Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation. Circulation. 2020;142 (13):1261-1278. doi: 10.1161/CIRCULATIONAHA.119.044127. PubMed PMID:32686471 PubMed Central PMC9277750.
  16. Bose, RJC, McCarthy, JR. Direct SARS-CoV-2 infection of the heart potentiates the cardiovascular sequelae of COVID-19. Drug Discov Today. 2020;25 (9):1559-1560. doi: 10.1016/j.drudis.2020.06.021. PubMed PMID:32592868 PubMed Central PMC7313487.
  17. Burashnikov, A, Barajas-Martinez, H, Hu, D, Robinson, VM, Grunnet, M, Antzelevitch, C et al.. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020;76 (2):164-172. doi: 10.1097/FJC.0000000000000855. PubMed PMID:32453071 PubMed Central PMC7416459.
  18. Gussak, G, Marszalec, W, Yoo, S, Modi, R, O'Callaghan, C, Aistrup, GL et al.. Triggered Ca2+ Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes. Circ Arrhythm Electrophysiol. 2020;13 (6):e008179. doi: 10.1161/CIRCEP.119.008179. PubMed PMID:32433891 PubMed Central PMC7340345.
  19. Lahrouchi, N, Tadros, R, Crotti, L, Mizusawa, Y, Postema, PG, Beekman, L et al.. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome. Circulation. 2020;142 (4):324-338. doi: 10.1161/CIRCULATIONAHA.120.045956. PubMed PMID:32429735 PubMed Central PMC7382531.
  20. Raveendran, VV, Al-Haffar, K, Kunhi, M, Belhaj, K, Al-Habeeb, W, Al-Buraiki, J et al.. Protein arginine methyltransferase 6 mediates cardiac hypertrophy by differential regulation of histone H3 arginine methylation. Heliyon. 2020;6 (5):e03864. doi: 10.1016/j.heliyon.2020.e03864. PubMed PMID:32420474 PubMed Central PMC7218648.
  21. Tucker, NR, Chaffin, M, Fleming, SJ, Hall, AW, Parsons, VA, Bedi, KC Jr et al.. Transcriptional and Cellular Diversity of the Human Heart. Circulation. 2020;142 (5):466-482. doi: 10.1161/CIRCULATIONAHA.119.045401. PubMed PMID:32403949 PubMed Central PMC7666104.
  22. Jing, JLJ, Pei Yi, T, Bose, RJC, McCarthy, JR, Tharmalingam, N, Madheswaran, T et al.. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations. Int J Environ Res Public Health. 2020;17 (9):. doi: 10.3390/ijerph17093326. PubMed PMID:32403261 PubMed Central PMC7246736.
  23. Bose, RJC, Tharmalingam, N, Garcia Marques, FJ, Sukumar, UK, Natarajan, A, Zeng, Y et al.. Reconstructed Apoptotic Bodies as Targeted "Nano Decoys" to Treat Intracellular Bacterial Infections within Macrophages and Cancer Cells. ACS Nano. 2020;14 (5):5818-5835. doi: 10.1021/acsnano.0c00921. PubMed PMID:32347709 PubMed Central PMC9116903.
  24. Musa, H, Marcou, CA, Herron, TJ, Makara, MA, Tester, DJ, O'Connell, RP et al.. Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk. Am J Physiol Heart Circ Physiol. 2020;318 (6):H1357-H1370. doi: 10.1152/ajpheart.00481.2019. PubMed PMID:32196358 PubMed Central PMC7311695.
  25. Shiferaw, Y, Aistrup, GL, Louch, WE, Wasserstrom, JA. Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes. Biophys J. 2020;118 (2):476-491. doi: 10.1016/j.bpj.2019.12.012. PubMed PMID:31889516 PubMed Central PMC6976802.
  26. Chen, J, Ma, Q, King, JS, Sun, Y, Xu, B, Zhang, X et al.. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020;3 (1):. doi: 10.26508/lsa.201900424. PubMed PMID:31843959 PubMed Central PMC6918510.
  27. Gripp, KW, Schill, L, Schoyer, L, Stronach, B, Bennett, AM, Blaser, S et al.. The sixth international RASopathies symposium: Precision medicine-From promise to practice. Am J Med Genet A. 2020;182 (3):597-606. doi: 10.1002/ajmg.a.61434. PubMed PMID:31825160 PubMed Central PMC7021559.
  28. Perenthaler, E, Nikoncuk, A, Yousefi, S, Berdowski, WM, Alsagob, M, Capo, I et al.. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Acta Neuropathol. 2020;139 (3):415-442. doi: 10.1007/s00401-019-02109-6. PubMed PMID:31820119 PubMed Central PMC7035241.
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