Aistrup Lab

Dr. Aistrup’s research lab focuses on the basis of cardiac arrhythmias – irregular heart beat rates. Cardiac arrhythmias can occur in both the lower (ventricles) and upper (atria) of the heart, and while ventricular arrhythmias pose greater risk to life as they can lead to sudden cardiac death, atrial arrhythmias – i.e., atrial fibrillation – are the most common and while not immediately life-threatening can lead to stroke and heart failure. These arrhythmias can arise by several means consequent to heart disease (e.g., heart failure), myocardial infarctions or genetic anomalies resulting in ion channelopathies (e.g., long or short QT syndromes, Brugada syndrome) and/or cardiomyopathies (hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia). Dr. Aistrup’s main line of cardiac arrhythmia investigation is on how atypical calcium signaling in cardiomyocytes (heart muscle cells) contributes to arrhythmogenesis. Calcium is key in cardiac excitation-contraction (E-C) coupling – the cellular/molecular processes that underlie the heartbeat – and therefore any perturbation to calcium handling will affect heart function.

Moreover, as cardiac E-C coupling must be dynamic to meet the bodies changing demands, it is vitally modulated by multiple cell-signaling systems such as the autonomic (‘fight-or-flight’ and ‘rest-and-digest’ responses) and renin-angiotensin (blood pressure regulation) G-protein coupled receptor (GPCR) systems. His laboratory engages in the study of proarrhythmic abnormalities in both core E-C coupling and its modulatory systems, particularly under conditions of or leading to heart failure, and employs multiple methodologies to do so – i.e., cellular and tissue-level electrophysiology and live subcellular calcium imaging, as well as various immunological and molecular biological assays. While much of Dr. Aistrup’s research relies on utilizing both small and large animal models, upon joining the Masonic Medical Research Institute (MMRI), his laboratory has recently begun to incorporate human induced pluripotent stem cell-derived cardiomyocytes (h_iPSC-CMs) into his research, specifically to utilize them in the characterization and potential correction of genetic mutation-induced cardiac arrhythmias.

The overall goal of Dr. Aistrup’s research to elucidate and precisely characterize aberrant cellular/molecular underpinnings of cardiac arrhythmogenesis is to provide the basis for not only improved but patient-specific anti-arrhythmic therapies.

 

Research Assistant Professor, Masonic Medical Research Institute

Email : , Phone : 315-624-7486

 

 

 

Dr. Aistrup began his research career working upon obtaining his PhD in biochemistry in the laboratories of Dr. Elias Michaelis, MD, PhD and Dr. Richard Schowen, PhD (Department of Chemistry) at the University of Kansas (title of dissertation: “Functional Reconstitution and Ion Channel Characterization of a NMDA/Glutamate Receptor in Planar Lipid Bilayers”). He went on to do a postdoctoral fellowship in the laboratory of Dr. Toshio Narahashi, PhD (Department of Molecular Pharmacology & Biological Chemistry) at Northwestern University Feinberg School of Medicine, where he investigated the alcohol action on GABAA and neuronal nicotinic acetylcholine receptor-ion channels. In 2000, Dr. Aistrup did another short-term postdoc in the laboratory of Richard Morrisett, PhD (Department of Pharmacology & Toxicology) at the University of Texas, Austin, studying amino acid synaptic transmission before returning to Northwestern University Feinberg School of Medicine in 2001 as a Research Assistant Professor in the Department of Molecular Pharmacology & Biological Chemistry. His initial research focus at Northwestern was on alcohol modulation of L-type calcium channels, which he quickly expanding to encompass alcohol effects on cardiac E-C coupling upon establishing a very productive collaboration with Dr. J. Andrew Wasserstrom, PhD (Department of Medicine, Division of Cardiology). Dr. Wasserstrom and Dr. Alan Kadish, MD (Department of Medicine, Division of Cardiology, Director of Clinical Electrophysiology) soon thereafter in 2004 recruited Dr. Aistrup to the Feinberg Cardiovascular Research Institute where he continued his collaborations with Dr. Wasserstrom and turning his research focus to the study of abnormal calcium release events during cardiac. In 2006, Dr. Aistrup established another productive collaboration with physician-scientist, Dr. Rishi Arora, investigating autonomic and oxidative stress modulation of atrial E-C coupling and electrophysiology in large-animal models of heart failure and atrial fibrillation. These research endeavors resulted in Dr. Aistrup being investigators on multiple NIH-funded grant projects, and allowed his rise to the rank of Research Associate Professor at the Feinberg Cardiovascular Institute. In latter part of 2016, was recruited to the Masonic Medical Research Institute as a Principle Research Scientist by Dr. Jonathan Cordeiro, PhD (interim Research Director).

Training

Dr. Aistrup earned a bachelor’s degree in Chemistry from Fort Hays State University, Hays KS, and obtained his PhD in Biology/Biochemistry under Dr. Elias Michaelis, MD, PhD and Dr. Richard Schowen, PhD at the University of Kansas, Lawrence KS. He did his postdoctoral training in molecular pharmacology and cellular electrophysiology with Toshio Narahashi, PhD at Northwestern University.

 

Why Masonic Medical Research Institute

A great opportunity to expand upon ongoing and develop new forward-looking biomedical research alongside newly recruited faculty and Director.

 

Affiliations

- Heart Rhythm Society

- American Physiological Society

- Biophysical Society

- Cardiac Electrophysiology Society

- American Heart Association

 

Professional titles

- Principle Scientist/Assistant Professor, Masonic Medical Research Institute (2016-2020)

- Research Associate Professor, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine (2014-2016)

 

Education

- 1988 – BS, Chemistry Fort Hays State University

- 1994 – PhD, Biochemistry University of Kansas

 

Honors and Awards

- Royal Danish Academy of Science Annual Ion Channel Symposium Invited Speaker (2012, Copenhagen, Denmark)

- Research Society on Alcoholism Annual Scientific Meeting Invited Symposium Speaker (1999, Santa Barbara, CA)

- F32 Postdoctoral Fellowship Award (1996-1999) – “Ethanol on GABAA and Nicotinic Acetylcholine Receptor Intracellular Regulation”.

  1. Malinowski, DP, Broache, M, Vaughan, L, Andrews, J, Gary, D, Kaufman, HW et al.. Cotesting in Cervical Cancer Screening. Am J Clin Pathol. 2020; :. doi: 10.1093/ajcp/aqaa169. PubMed PMID:33270087 .
  2. Hughes, DJ, Chand, G, Goh, V, Cook, GJR. Inter- and intraobserver agreement of the quantitative assessment of [99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer. EJNMMI Res. 2020;10 (1):145. doi: 10.1186/s13550-020-00734-x. PubMed PMID:33259032 .
  3. Jain, P, McKinnell, K, Marino, R, Vunnava, P, Liles-Burden, MA, Desai, A et al.. Evaluation of Opioid Overdose Reports in Patients Treated with Extended-Release Naltrexone: Postmarketing Data from 2006 to 2018. Drug Saf. 2020; :. doi: 10.1007/s40264-020-01020-4. PubMed PMID:33258068 .
  4. Lee, S, Li, G, Liu, T, Tse, G. COVID-19: Electrophysiological mechanisms underlying sudden cardiac death during exercise with facemasks. Med Hypotheses. 2020;144 :110177. doi: 10.1016/j.mehy.2020.110177. PubMed PMID:33254499 .
  5. Gressenberger, P, Portugaller, RH, Gütl, K, Muster, V, Jud, P, Schmid, J et al.. J Dtsch Dermatol Ges. 2020;18 (11):1322-1324. doi: 10.1111/ddg.14258_g. PubMed PMID:33251734 .
  6. Hérard, AS, Petit, F, Gary, C, Guillermier, M, Boluda, S, Garin, CM et al.. Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains. Acta Neuropathol Commun. 2020;8 (1):205. doi: 10.1186/s40478-020-01081-7. PubMed PMID:33250056 .
  7. Novack, GARYD. Repurposing Medications. Ocul Surf. 2020; :. doi: 10.1016/j.jtos.2020.11.012. PubMed PMID:33249292 PubMed Central PMC7690306.
  8. Behnke, AL, Parola, LR, Karamchedu, NP, Badger, GJ, Fleming, BC, Beveridge, JE et al.. Neuromuscular function in anterior cruciate ligament reconstructed patients at long-term follow-up. Clin Biomech (Bristol, Avon). 2020; :105231. doi: 10.1016/j.clinbiomech.2020.105231. PubMed PMID:33246796 .
  9. Boddaert, G, Cornut, C, Casalis, S. Integration of newly learned L2 words into the mental lexicon is modulated by vocabulary learning method. Acta Psychol (Amst). 2020;212 :103220. doi: 10.1016/j.actpsy.2020.103220. PubMed PMID:33246309 .
  10. Gurses, SA, Banskar, S, Stewart, C, Trimoski, B, Dziarski, R, Gupta, D et al.. Nod2 protects mice from inflammation and obesity-dependent liver cancer. Sci Rep. 2020;10 (1):20519. doi: 10.1038/s41598-020-77463-7. PubMed PMID:33239685 PubMed Central PMC7688964.
  11. Fields, K, Barngrover, BM, Gary, JB. Computational Investigation of the Preferred Binding Modes of N2O in Group 8 Metal Complexes. Inorg Chem. 2020; :. doi: 10.1021/acs.inorgchem.0c02903. PubMed PMID:33237746 .
  12. Jensen, KM, Campagna, EJ, Juarez-Colunga, E, Runyan, DK, Prochazka, AV. Predictors of Receipt of Clinical Preventive Services in Adolescents and Adults with Down Syndrome Accessing Medicaid. Disabil Health J. 2020; :101016. doi: 10.1016/j.dhjo.2020.101016. PubMed PMID:33229308 .
  13. Khan, AA, Rodriguez-Collazo, ER, Lo, E, Raja, A, Yu, S, Khan, HA et al.. Evaluation and Treatment of Foot Drop Using Nerve Transfer Techniques. Clin Podiatr Med Surg. 2021;38 (1):83-98. doi: 10.1016/j.cpm.2020.09.004. PubMed PMID:33220746 .
  14. Kisaakye, E, Ario, AR, Bainomugisha, K, Cossaboom, CM, Lowe, D, Bulage, L et al.. Outbreak of Anthrax Associated with Handling and Eating Meat from a Cow, Uganda, 2018. Emerg Infect Dis. 2020;26 (12):2799-2806. doi: 10.3201/eid2612.191373. PubMed PMID:33219644 .
  15. Wen, H, Zhu, H, Xu, Y, Yan, B, Shutes, B, Bañuelos, G et al.. Removal of sulfamethoxazole and tetracycline in constructed wetlands integrated with microbial fuel cells influenced by influent and operational conditions. Environ Pollut. 2020; :115988. doi: 10.1016/j.envpol.2020.115988. PubMed PMID:33218779 .
  16. Fausther-Bovendo, H, Kobinger, G. Vaccine innovation spurred by the long wait for an Ebola virus vaccine. Lancet Infect Dis. 2020; :. doi: 10.1016/S1473-3099(20)30515-6. PubMed PMID:33217364 .
  17. Mai, AD, Harton, GL, Quang, VN, Van, HN, Thi, NH, Thuy, NP et al.. Development and clinical application of a preimplantation genetic testing for monogenic disease (PGT-M) for beta thalassemia in Vietnam. J Assist Reprod Genet. 2020; :. doi: 10.1007/s10815-020-02006-y. PubMed PMID:33216308 .
  18. Triggs, JR, Falk, GW. Best Practices in Surveillance for Barrett's Esophagus. Gastrointest Endosc Clin N Am. 2021;31 (1):59-75. doi: 10.1016/j.giec.2020.08.003. PubMed PMID:33213800 PubMed Central PMC7684982.
  19. Abdel-Wahab, M, Fujita, B, Frerker, C, Bauer, T, Beckmann, A, Bekeredjian, R et al.. Transcatheter Versus Rapid-Deployment Aortic Valve Replacement: A Propensity-Matched Analysis From the German Aortic Valve Registry. JACC Cardiovasc Interv. 2020;13 (22):2642-2654. doi: 10.1016/j.jcin.2020.09.018. PubMed PMID:33213749 .
  20. King, J, Goldenberg, D, Goldstein, G, Hartung, W, Royer, C, Sundberg, E et al.. Congressional Budget Responses to the Pandemic: Fund Health Care, Not Warfare. Am J Public Health. 2020; :e1-e2. doi: 10.2105/AJPH.2020.306048. PubMed PMID:33211586 .
  21. Ge, T, Jiang, H, Johnson, SB, Larkin, R, Charkowski, AO, Secor, G et al.. Genotyping Dickeya dianthicola causing potato blackleg and soft rot outbreak associated with inoculum geography in the United States. Plant Dis. 2020; :. doi: 10.1094/PDIS-10-20-2138-RE. PubMed PMID:33210970 .
  22. Sibbald, RG, Elliott, JA, Coutts, P, Persaud-Jaimangal, R. Evaluation of Longitudinal and Tubular Compression Treatment for Lower Limb Edema. Adv Skin Wound Care. 2020;33 (12):643-649. doi: 10.1097/01.ASW.0000720264.41419.38. PubMed PMID:33208662 .
  23. Cousin, GC, Yousaf, I. Ludwig's angina: infected teeth must be extracted. BMJ. 2020;371 :m4466. doi: 10.1136/bmj.m4466. PubMed PMID:33208308 .
  24. Hamilton, KL, Sheehan, SA, Retzbach, EP, Timmerman, CA, Gianneschi, GB, Tempera, PJ et al.. Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways. J Cancer Res Clin Oncol. 2020; :. doi: 10.1007/s00432-020-03456-8. PubMed PMID:33205348 .
  25. Sawers, RG. Setting the Stage: Genes Controlling Mechanosensation and Ca2+-Signalling in E. coli. J Bacteriol. 2020; :. doi: 10.1128/JB.00595-20. PubMed PMID:33199281 .
  26. Hoque, S, Puenpatom, A, Boccaletti, S, Green, C, Black, CM, Roberts, J et al.. Treatment persistence and colectomy-free outcomes in patients with ulcerative colitis receiving golimumab or adalimumab: a UK experience. BMJ Open Gastroenterol. 2020;7 (1):. doi: 10.1136/bmjgast-2020-000476. PubMed PMID:33199269 PubMed Central PMC7670853.
  27. Sirunyan, AM, Tumasyan, A, Adam, W, Ambrogi, F, Bergauer, T, Dragicevic, M et al.. A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution. Comput Softw Big Sci. 2020;4 (1):10. doi: 10.1007/s41781-020-00041-z. PubMed PMID:33196702 PubMed Central PMC7659430.
  28. Lees, JP, Poireau, V, Tisserand, V, Grauges, E, Palano, A, Eigen, G et al.. Search for a Dark Leptophilic Scalar in e^{+}e^{-} Collisions. Phys Rev Lett. 2020;125 (18):181801. doi: 10.1103/PhysRevLett.125.181801. PubMed PMID:33196250 .
  29. Roberts, RA, Groot, G, Carr, T. Decisions on cancer care by Indigenous peoples in Alberta and Saskatchewan: a narrative analysis. Rural Remote Health. 2020;20 (4):5610. doi: 10.22605/RRH5610. PubMed PMID:33190506 .
  30. Brown, DE, Landry, HV. In memoriam: Gary D. James (1954-2020). Am J Hum Biol. 2020; :e23536. doi: 10.1002/ajhb.23536. PubMed PMID:33188553 .
  31. de Vladar, HP. GARY TOMLINSON, Culture and the Course of Human Evolution, Chicago: The University of Chicago Press, 2018, 202 pp. Hist Philos Life Sci. 2020;42 (4):56. doi: 10.1007/s40656-020-00349-4. PubMed PMID:33188475 .
  32. Gouwens, NW, Sorensen, SA, Baftizadeh, F, Budzillo, A, Lee, BR, Jarsky, T et al.. Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells. Cell. 2020;183 (4):935-953.e19. doi: 10.1016/j.cell.2020.09.057. PubMed PMID:33186530 .
  33. Greven, ACM, McGinley, BM, Guisse, NF, McGee, LJ, Pirkle, S, Malcolm, JG et al.. Telemedicine in the Evaluation and Management of Neurosurgical Spine Patients: Questionnaire Assessment of 346 Consecutive Patients. Spine (Phila Pa 1976). 2020; :. doi: 10.1097/BRS.0000000000003821. PubMed PMID:33186272 .
  34. Louw, A, Sidhu, C, Fitzgerald, DB, Creaney, J, Chai, SM, Lee, YCG et al.. Clump material within drainage chest tubes contain diagnostic information: A proof-of-concept case series. Eur Respir J. 2020; :. doi: 10.1183/13993003.03248-2020. PubMed PMID:33184118 .
  35. Scanzera, AC, Dunbar, G, Shah, V, Cortina, MS, Leiderman, YI, Shorter, E et al.. Visual Rehabilitation With Contact Lenses Following Open Globe Trauma. Eye Contact Lens. 2020; :. doi: 10.1097/ICL.0000000000000756. PubMed PMID:33181528 .
  36. Anon. Angela Nguku: for a societal approach to primary health care. Bull World Health Organ. 2020;98 (11):733-734. doi: 10.2471/BLT.20.031120. PubMed PMID:33177769 PubMed Central PMC7607471.
  37. Anon. Digital health and COVID-19. Bull World Health Organ. 2020;98 (11):731-732. doi: 10.2471/BLT.20.021120. PubMed PMID:33177768 PubMed Central PMC7607467.
  38. Kerimi, A, Kraut, NU, da Encarnacao, JA, Williamson, G. The gut microbiome drives inter- and intra-individual differences in metabolism of bioactive small molecules. Sci Rep. 2020;10 (1):19590. doi: 10.1038/s41598-020-76558-5. PubMed PMID:33177581 PubMed Central PMC7658971.
  39. Reynolds, QJ, Gilliland, KO, Smith, K, Walker, JA, Beck Dallaghan, GL. Differences in medical student performance on examinations: exploring score variance between Kolb's Learning Style Inventory classifications. BMC Med Educ. 2020;20 (1):423. doi: 10.1186/s12909-020-02353-5. PubMed PMID:33176776 PubMed Central PMC7661198.
  40. Naureen, Z, Beccari, T, Marks, RS, Brown, R, Lorusso, L, Pheby, D et al.. Ethics committees for clinical experimentation at international level with a focus on Italy. Acta Biomed. 2020;91 (13-S):e2020016. doi: 10.23750/abm.v91i13-S.10643. PubMed PMID:33170165 .
  41. Visvanathan, R, Houghton, MJ, Williamson, G. Maltoheptaoside hydrolysis with chromatographic detection and starch hydrolysis with reducing sugar analysis: Comparison of assays allows assessment of the roles of direct α-amylase inhibition and starch complexation. Food Chem. 2020; :128423. doi: 10.1016/j.foodchem.2020.128423. PubMed PMID:33168261 .
  42. England, GCW, Rijsselaere, T, Campbell, A, Moxon, R, Freeman, SL. Normal and abnormal response to sperm deposition in female dogs: A review and new hypotheses for endometritis. Theriogenology. 2021;159 :176-183. doi: 10.1016/j.theriogenology.2020.10.013. PubMed PMID:33160112 .
  43. Shahhosseini, N, Frederick, C, Racine, T, Kobinger, GP, Wong, G. Modeling host-feeding preference and molecular systematics of mosquitoes in different ecological niches in Canada. Acta Trop. 2020;213 :105734. doi: 10.1016/j.actatropica.2020.105734. PubMed PMID:33159902 .
  44. Thompson, BL, Oscar-Berman, M, Kaplan, GB. Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens. Neurosci Biobehav Rev. 2020; :. doi: 10.1016/j.neubiorev.2020.10.015. PubMed PMID:33152423 .
  45. Gary, AS, Rochette, PJ. Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiation. Sci Rep. 2020;10 (1):18946. doi: 10.1038/s41598-020-75873-1. PubMed PMID:33144600 PubMed Central PMC7609555.
  46. Cao, Q, Yang, N, Wang, Y, Xu, C, Zhang, X, Fan, K et al.. Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates. Sci Signal. 2020;13 (656):. doi: 10.1126/scisignal.aaz1529. PubMed PMID:33144518 .
  47. Ten Eyck, GR, Ten Eyck, LM. Serotonin and vasotocin function in territoriality. Pharmacol Biochem Behav. 2020;199 :173068. doi: 10.1016/j.pbb.2020.173068. PubMed PMID:33144208 .
  48. Choi, K, Chen, Y, Skelly, DA, Churchill, GA. Publisher Correction: Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics. Genome Biol. 2020;21 (1):270. doi: 10.1186/s13059-020-02182-1. PubMed PMID:33143736 PubMed Central PMC7607620.
  49. Gedarawatte, STG, Ravensdale, JT, Al-Salami, H, Dykes, GA, Coorey, R. Antimicrobial efficacy of nisin-loaded bacterial cellulose nanocrystals against selected meat spoilage lactic acid bacteria. Carbohydr Polym. 2021;251 :117096. doi: 10.1016/j.carbpol.2020.117096. PubMed PMID:33142634 .
  50. Trager, MH, Lavian, J, Lee, EY, Gary, D, Jenkins, F, Christiano, AM et al.. Prevalence Estimates for Lichen Planopilaris and Frontal Fibrosing Alopecia in a New York City Health Care System. J Am Acad Dermatol. 2020; :. doi: 10.1016/j.jaad.2020.10.081. PubMed PMID:33137442 .
  51. Warnakula, IK, Ebrahimpour, A, Li, SY, Gaspe Ralalage, RD, Hewa-Rahinduwage, CC, Kiss, M et al.. Evaluation of the Long-Term Storage Stability of the Cyanide Antidote: Dimethyl Trisulfide and Degradation Product Identification. ACS Omega. 2020;5 (42):27171-27179. doi: 10.1021/acsomega.0c03208. PubMed PMID:33134677 PubMed Central PMC7594147.
  52. Kalra, S, Aydin, H, Sahay, M, Ghosh, S, Ruder, S, Tiwaskar, M et al.. Cardiorenal Syndrome in Type 2 Diabetes Mellitus - Rational Use of Sodium-glucose Cotransporter-2 Inhibitors. Eur Endocrinol. 2020;16 (2):113-121. doi: 10.17925/EE.2020.16.2.113. PubMed PMID:33117442 PubMed Central PMC7572171.
  53. Baker, CE, Kiebzak, GM, Neal, KM. Anterior vertebral body tethering shows mixed results at 2-year follow-up. Spine Deform. 2020; :. doi: 10.1007/s43390-020-00226-x. PubMed PMID:33113121 .
  54. Gajaweera, H, Oladele, D, Connett, G. Evaluation of the impact of shielding to avoid COVID-19 infection on respiratory symptoms in children with severe asthma. Arch Dis Child. 2020; :. doi: 10.1136/archdischild-2020-320498. PubMed PMID:33109523 .
  55. Bonde, J, Bottari, F, Iacobone, AD, Cocuzza, CE, Sandri, MT, Bogliatto, F et al.. Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review. J Low Genit Tract Dis. 2020; :. doi: 10.1097/LGT.0000000000000573. PubMed PMID:33105450 .
  56. Djulbegovic, B, Razavi, M, Hozo, I. When are randomized trials unnecessary? A signal detection theory approach to approving new treatments based on non-randomized studies. J Eval Clin Pract. 2020; :. doi: 10.1111/jep.13497. PubMed PMID:33103322 .
  57. Liu, F, Zou, Z, Peng, G, Fernando, WGD. Leptosphaeria maculans isolates reveal their allele frequency in western Canada. Plant Dis. 2020; :. doi: 10.1094/PDIS-08-20-1838-RE. PubMed PMID:33100150 .
  58. Li, M, Yamada, S, Shi, A, Singh, RD, Rolland, TJ, Jeon, R et al.. Brachyury engineers cardiac repair competent stem cells. Stem Cells Transl Med. 2020; :. doi: 10.1002/sctm.20-0193. PubMed PMID:33098750 .
  59. Davies, SJ, Minto, G. Occam's razor at the sharp end: simplified preoperative risk assessment. Br J Anaesth. 2020; :. doi: 10.1016/j.bja.2020.09.015. PubMed PMID:33097181 .
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